Siberian mouse model nude3/17/2024 ![]() ![]() Circadian misalignment and sleep deprivation and/or sleep disturbances have profound effects on physical and mental health and performance. Of particular concern is additional east-west travel that results in circadian rhythm disruptions commonly called jet lag that contribute to the loss of amount as well as quality of sleep. These rearrangements will require more multi-day travel that interferes with the academic work and personal schedules of athletes. These concerns are made more acute by recent proposals and decisions to reorganize major collegiate athletic conferences. Clearly such stressors can have negative impacts on both their academic and athletic performances as well as on their health. Other applications include reduction of symptoms in MS patients and going back to our original work, perioperative temperature management of human and veterinary patients.Ĭollegiate athletes must satisfy the academic obligations common to all undergraduates, but they have the additional structural and social stressors of extensive practice time, competition schedules, and frequent travel away from their home campus. and any other individuals who have to work in the high heat or while being encapsulated for protection from biological or radiological hazards. Additional applications include continuous cooling of workers in personal protection gear such as that worn by fire-fighters and hazmat workers. ![]() A commercial version of this technology is now used in athletics. ![]() Increasing work volume dramatically increases physical conditioning. Using such devices, the lab discovered that the major cause of muscle fatigue and failure is rise in temperature of the muscle, and extraction of heat leads to rapid recovery and continued work capacity. Subsequently the lab developed a technology to rapidly extract heat from the body through one or more of these surfaces. A resulting discovery was that the primary heat exchange body surfaces of humans are the glabrous skin of the palms, soles, and face. This work led to the development of a post-anesthesia method to rewarm patients. Heller has studied the brain control of body temperature in mammals for many years, much of it focused on hibernation. The second area of the Heller lab’s research is human temperature regulation. This work has led to the discovery of a previously unrecognized function of circadian rhythms that promotes the consolidation of memories during sleep. One of these compounds has already been in phase 2 clinical studies. This work has resulted in identification of a class of drugs that restores the ability to learn and remember in mouse models of Down syndrome. The focus in the first area of the lab’s work is on the learning disability of Down syndrome. Heller’s laboratory currently works in two rather different areas: The roles of sleep and circadian rhythms in learning and memory, and human temperature regulation. Vice Provost for Undergraduate Educationĭr.Office of Vice President for Business Affairs and Chief Financial Officer.Office of VP for University Human Resources. ![]()
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